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Target intelligence / Profile preview
Talin rod domain-containing protein 1 (TLNRD1)
- Target
- TLNRD1
- Molecular classification
- Other, Actin-binding protein, Cytoskeletal protein
01
Overview
Talin rod domain-containing protein 1 (TLNRD1) is an α-helical actin-binding protein structurally homologous to the talin R7R8 rod domain, capable of binding and bundling F-actin through dimerization[1][5]. It participates in the promotion of filopodia formation and regulates cell proliferation, migration, and invasion, especially in cancer cells[1][2][5]. TLNRD1 is thought to possess potential oncogenic functions and its expression is regulated by microRNA (such as miR-574-3)[2][3][4]. It also interacts with other multidomain proteins containing LD motifs, such as RIAM and KANK, indicating a role in actin cytoskeleton regulation and cell motility[1]. While associated with cancer and cellular migration processes, there are no established drugs directly targeting TLNRD1 nor is it an established therapeutic target in current practice[4][5].
- Other names
- Mesoderm development candidate 1MESDC1MGC99595Talin rod domain containing 1TLRN1
02
Biological functions
Actin bindingActin-bundlingRegulation of cell migrationRegulation of cell proliferationPromotion of filopodia formationCell invasion
03
Disease associations
Cancer (including roles in bladder cancer)Other (possible function in early developmental processes)
04
Biomarkers
Potential oncogenic biomarker (not clinically validated as a routine biomarker)
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