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Target intelligence / Profile preview
TAM family receptors (TAM)
- Target
- TAM
- Molecular classification
- Receptor, Receptor tyrosine kinases (RTKs)
01
Overview
The TAM family receptors (Tyro3, Axl, Mer) are receptor tyrosine kinases that play critical roles in immune homeostasis, efferocytosis, hemostasis, and cell survival/proliferation. They are activated by ligands Gas6 and Protein S, which bind to their extracellular Ig-like domains, leading to receptor dimerization and activation of intracellular signaling pathways. Dysregulation of TAM receptors is implicated in various diseases, including autoimmune disorders, inflammation, thrombosis, and cancer.
02
Mechanism of action
Ligand binding (Gas6, Protein S) leading to receptor dimerization, autophosphorylation, and downstream signaling cascades.
03
Biological functions
Immune regulationEfferocytosisHemostasisCell survivalCell proliferationCell adhesionCell migrationNervous system development
04
Disease associations
Autoimmune diseasesChronic inflammatory conditionsInfectious diseasesThromboembolic diseaseAtherosclerosisSepsisCancer
05
Safety considerations
Dual role in cancer (tumor growth regulation and anti-tumor immunity modulation) requires careful consideration in therapeutic targeting.
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