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Two-Pore-Domain Potassium Channel (K2P)
- Target
- K2P
- Molecular classification
- Ion channel, Potassium channel, Two-pore-domain potassium channel
01
Overview
Two-pore-domain potassium channels (K2P channels) are a family of potassium ion channels that play a crucial role in maintaining the resting membrane potential and regulating cellular excitability in both excitable and non-excitable cells. They are dimeric channels with each subunit containing two pore-forming domains. K2P channels conduct quasi-instantaneous, noninactivating outward K⁺ currents, contributing to the background or leak conductance. Their activity is modulated by diverse physiological stimuli, and they participate in various physiological and pathophysiological processes.
- Other names
- Tandem pore domain potassium channelBackground potassium channelLeak potassium channel
02
Mechanism of action
Modulation of channel activity by lipids, pH, mechanical stimuli, G-proteins, temperature, and various pharmacological agents.
03
Biological functions
Ion homeostasisRegulation of resting membrane potentialCellular excitabilityHormone secretionCell developmentCell differentiationModulation of neuronal excitabilityModulation of muscular excitability
04
Disease associations
Vascular hypertensionPulmonary hypertensionCardiac arrhythmiasNociceptionNeuroprotectionDepression
05
Interacting drugs
Volatile anesthetics (e.g., TASK/TREK family)
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