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Tankyrase (None)
- Target
- None
- Molecular classification
- Enzyme, Poly(ADP-ribose) polymerase family
01
Overview
Tankyrase refers to a family of multifunctional enzymes, specifically poly(ADP-ribose) polymerases (PARPs), that play critical roles in several cellular processes. In humans, the two main tankyrases are Tankyrase 1 (TNKS1) and Tankyrase 2 (TNKS2). These enzymes catalyze poly(ADP-ribosyl)ation (PARylation), regulating telomere homeostasis, Wnt/β-catenin signaling, cell cycle progression, and other cellular functions. Tankyrases have been implicated in cancer and other diseases and are a target for small molecule inhibitors primarily developed for cancer therapy.
- Other names
- TNKSTNKS1TNKS2ARTD5ARTD6PARP5APARP5B
02
Mechanism of action
Tankyrase inhibitors suppress Wnt/β-catenin signaling by stabilizing AXIN proteins, leading to reduced cell proliferation and differentiation.
03
Biological functions
Telomere maintenanceWnt/β-catenin pathway regulationCell cycle progressionMitosis regulationVesicle traffickingGlucose metabolism
04
Disease associations
CancerCherubismFocal Segmental Glomerulosclerosis
05
Interacting drugs
Tankyrase inhibitors
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