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Target intelligence / Profile preview
Poly(ADP-ribose) Polymerase 5a (TNKS1)
- Target
- TNKS1
- Molecular classification
- Enzyme, Poly(ADP-ribose) polymerase (PARP), ARTD superfamily, Diphtheria toxin-like ADP-ribosyltransferases (ARTDs)
01
Overview
Poly(ADP-ribose) polymerase 5a, also known as Tankyrase 1 (TNKS1), is an enzyme that catalyzes the transfer of ADP-ribose units to target proteins, regulating their function and stability. It plays critical roles in telomere maintenance, Wnt signaling activation, cell cycle progression, and DNA damage response. As a regulator of pathways central to cancer biology, particularly Wnt signaling, TNKS1 is an attractive target for anticancer drug development.
- Other names
- Tankyrase 1PARP5aARTD5TNKS
02
Mechanism of action
Inhibition of PARsylation activity, stabilization of negative regulators of Wnt signaling and telomere maintenance proteins
03
Biological functions
Telomere maintenanceWnt signaling activationCell cycle regulationDNA damage responseGlucose metabolismMyogenesis
04
Disease associations
CancerCancer progression/metastasis
05
Safety considerations
Potential for bone loss due to role in bone homeostasisPotential for off-target effects due to redundancy with TNKS2
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