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Tankyrase 2 (TNKS2)

Target: TNKS2
Molecular classification: Enzyme, Poly(ADP-ribose) polymerase (PARP)

Overview

Tankyrase 2 (TNKS2) is a poly(ADP-ribose) polymerase (PARP) enzyme that plays a critical role in several cellular processes, including Wnt/β-catenin signaling, telomere maintenance, vesicle trafficking, and proteasome activity. It catalyzes the addition of poly(ADP-ribose) chains to target proteins, regulating their function. TNKS2 is considered a therapeutic target, particularly in cancer where aberrant Wnt signaling or telomere dynamics contribute to tumorigenesis. Inhibitors targeting Tankyrases are under development.

Other names: PARP5BTANK2TNKLTRF1-interacting ankyrin-related ADP-ribose polymerase 2

Mechanism of action

Inhibition of Tankyrase activity, leading to modulation of Wnt signaling and telomere dynamics.

Biological functions

Poly(ADP-ribosyl)ationWnt/β-catenin signalingTelomere maintenanceVesicle traffickingProteasome activity

Disease associations

Cancer

Safety considerations

Potential for off-target effects due to similarity with Tankyrase 1Embryonic lethality observed in double knockout mice

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