Target intelligence / Profile preview

Taperin (TPRN)

Target: TPRN
Molecular classification: Other

Overview

Taperin (TPRN) is a structural/regulatory protein concentrated at the taper region of cochlear hair cell stereocilia, essential for their integrity and function. Mutations cause autosomal recessive deafness; there are no drugs targeting taperin, and it is not considered a classic therapeutic target.

Other names: TaperinTPRNC9orf75DFNB79FLJ90254

Biological functions

Essential for hearingMaintenance of stereociliaActin cytoskeleton regulationPPP1CA inhibitionDNA damage repair

Disease associations

Deafness (autosomal recessive 79)Rare genetic deafness

Biomarkers

TPRN gene mutations for DFNB79 diagnosis

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