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Target intelligence / Profile preview
TAR DNA-binding protein 43 (TDP-43)
- Target
- TDP-43
- Molecular classification
- DNA-binding protein, RNA-binding protein, Transcription factor
01
Overview
TAR DNA-binding protein 43 (TDP-43) is a highly conserved, predominantly nuclear protein that plays critical roles in gene expression regulation, RNA processing, and cellular stress responses. It is best known for its involvement in neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD), where it forms pathological cytoplasmic inclusions.
- Other names
- transactive response DNA binding protein 43 kDaTARDBP
02
Biological functions
Transcription repressionAlternative splicing regulationmRNA stabilitymRNA transportMicroRNA processingDNA repairStress response
03
Disease associations
Amyotrophic Lateral Sclerosis (ALS)Frontotemporal Lobar Degeneration (FTLD)Neurodegenerative disease
04
Safety considerations
Aggregation propensityMislocalizationDisruption of RNA metabolism
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