TAR DNA binding protein pseudogene 2 (TARDBPP2)

TAR DNA binding protein pseudogene 2 (**TARDBPP2**) is a genomic sequence sharing high similarity with the functional TARDBP gene but lacks the ability to encode, transcribe, or translate a functional protein product. Pseudogenes such as TARDBPP2 may result from duplication or retrotransposition events in evolution but are generally considered nonfunctional in protein-coding capacity[6]. While the parental TARDBP gene and its protein product TDP-43 are critical for RNA processing, splicing, and have been implicated in neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia, there is no evidence that TARDBPP2 has a direct physiological or pathological activity, nor is it a current or probable therapeutic target[5][6].

Other names

TARDBPP2TARDBP pseudogene 2TAR DNA binding protein pseudogene 2