TAR DNA-binding protein pseudogene 4 (TARDBPP4)

TARDBP pseudogene 4 (abbreviated TARDBPP4) is presumed to be a pseudogene of the TARDBP gene based on nomenclature and genomic databases. The canonical gene, TARDBP, encodes the RNA/DNA-binding protein TDP-43, which is widely expressed and involved in transcription regulation, RNA splicing, and several cellular processes, and is known for its pathogenic aggregation in neurodegenerative disorders such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia[1][4][6]. TARDBP pseudogene 4, however, is not considered to encode a functional protein and is not recognized as a molecular target or therapeutic receptor; current scientific databases provide no evidence of a biological, pathological, or therapeutic role for this pseudogene[5][6].

Other names

TARDBP pseudogene 4TARDBPP4