Targeting cancer cells through physical and radiological interactions

This is not a single molecular target but a therapeutic strategy in oncology that uses physical interventions (such as localized radiation therapy) and molecularly targeted agents to selectively damage or destroy cancer cells. It is based on the principle of combining locoregional treatments with systemic or molecular interventions for improved tumor control and minimal normal tissue toxicity[1]. The approach may exploit the unique biology of cancer cells, their microenvironment, and DNA damage response mechanisms, but does not refer to a specific receptor, enzyme, or transporter as a drug target[1][3]. If you are interested in *specific* molecular targets for which combination with radiation therapy is clinically validated (e.g., epidermal growth factor receptor, EGFR), or specific radiopharmaceutical agents, those can be further specified and would then have structured, parsable details. In that case, please clarify the specific target of interest (e.g., EGFR, immune checkpoint proteins, DNA repair enzymes) for targeted, structured data.