Targeting protein for Xklp2 (TPX2)

Targeting protein for Xklp2 (TPX2) is a microtubule-associated spindle assembly factor required for the nucleation and organization of microtubules during mitosis and meiosis[1][2][3][4]. It interacts with tubulin to stimulate microtubule nucleation, coordinates spindle assembly around chromosomes, and is regulated by the Ran-GTP-importin pathway[1][2][4]. TPX2 activates and recruits Aurora A kinase to the spindle, is necessary for proper bipolar spindle formation, and participates in both de novo and branching microtubule nucleation[1][2][3][4][5]. In cancer, TPX2 is often overexpressed, making it a proliferation-associated marker and potential prognostic biomarker in several malignancies; however, no direct drug targets or approved therapies against TPX2 exist at present[1].

Other names

C20orf1C20orf2DIL2DIL-2HCA519FLS353p100Differentially expressed in cancerous and non-cancerous lung cells 2Hepatocellular carcinoma-associated antigen 519Hepatocellular carcinoma-associated antigen 90Protein fls353Restricted expression proliferation-associated protein 100REPP86HCTP4