Taste receptor type 2 member 19 (TAS2R19)

Taste receptor type 2 member 19 (TAS2R19) is a member of the bitter taste receptor family. It is a seven-transmembrane domain G protein-coupled receptor expressed primarily in sensory cells of the oral cavity. TAS2R19 is responsible for detecting bitter-tasting chemicals, many of which are plant metabolites and potential toxins. Activation of this receptor initiates a G protein-dependent signaling cascade that leads to calcium mobilization and neurotransmitter release, forming part of the body's defense against ingestion of harmful substances. While its main biological function is taste perception, variations or altered expression may be associated with disease states such as submandibular gland disorders

Other names

TAS2R19TAS2R23TAS2R48T2R48T2R19T2R23MSTP058taste receptor type 2 member 23taste receptor type 2 member 48

Activation by bitter compounds triggers GPCR-mediated intracellular signaling, leading to sensory perception of bitterness