Taste receptor type 2 member 62 pseudogene (TAS2R62P)

Taste receptor type 2 member 62 pseudogene (TAS2R62P) is a member of the bitter taste receptor gene family (TAS2Rs), which encode G protein-coupled receptors involved in the detection of bitter compounds and initiation of taste transduction pathways[1][2]. In humans, TAS2R62P is classified as a pseudogene due to multiple loss-of-function mutations (two fixed nonsense mutations and a two-base deletion), rendering it non-functional[2][3]. It is human lineage-specific, arising from relaxations in selective pressures on bitter taste perception during recent primate evolution, with no known protein product or biological activity in Homo sapiens[2]. The functional orthologues in other primates may contribute to species-specific bitter taste adaptation, but TAS2R62P does not act as a therapeutic or biological target in humans[2][3].\n\nNotes: \n- TAS2R62P does not code for a functional protein in humans and is not considered a therapeutic target.\n- There is no evidence for pharmacological agents/drugs, biomarkers, or safety concerns associated with this pseudogene.\n- The loss of this receptor reflects human dietary evolution and does not, on its own, contribute to disease[2][3].

Other names

T2R62TAS2R62PS1taste 2 receptor member 62taste receptor, type 2, member 62, pseudogene