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Target intelligence / Profile preview
Taste receptor type 2 member 9 (TAS2R9)
- Target
- TAS2R9
- Molecular classification
- G protein-coupled receptor, Receptor
01
Overview
Taste receptor type 2 member 9 (TAS2R9) is a member of the G protein-coupled receptor (GPCR) superfamily, specifically involved in detecting bitter compounds in the oral cavity and the gastrointestinal tract. TAS2R9 is expressed in taste receptor cells clustered in the tongue and palate epithelia and signals via gustducin-mediated pathways, leading to increased intracellular calcium and depolarization, which transmits taste signals to the nervous system. Genetic variation in TAS2R9 can influence bitter taste perception and may have metabolic implications, such as influencing glucose homeostasis.
- Other names
- T2R9TRB6Taste receptor family B member 6
02
Mechanism of action
Activation by bitter-tasting ligands leads to signaling through gustducin, PLCB2, and TRPM5 resulting in taste cell depolarization and neurotransmitter release
03
Biological functions
Perception of bitter tasteSignal transduction
04
Disease associations
Other (altered function may contribute to dysregulated glucose homeostasis)
05
Interacting drugs
Data on specific drugs is limited; interacts with various bitter compounds in experimental models
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