TATA-binding protein-associated factor 15 (TAF15)

"Novel transcript, sense overlapping TAF15", ENSG00000270894, is annotated as a non-coding RNA gene with overlap to TAF15; it does not encode a well-characterized therapeutic target or receptor. The canonical protein encoded by TAF15 (TATA-binding protein-associated factor 15) is a member of the FET family of atypical RNA-binding proteins, participating in gene regulation at both the transcriptional and post-transcriptional levels. TAF15 has roles in RNA splicing, mRNA maturation, and is subject to regulation by phosphorylation (e.g., via cAMP-PKA signaling), impacting its RNA-binding pattern[3]. TAF15 is implicated in neural development, particularly dorsoanterior structures, and has disease associations including ALS and several cancers[3][4]. However, "novel transcript, sense overlapping TAF15" (ENSG00000270894) itself is not a canonical receptor, enzyme, or druggable therapeutic target as currently defined, but rather an uncharacterized RNA, and thus is likely a non-coding transcript or annotation artifact[1]. \n\n**Note:** \n- The main entry here is not a protein-coding therapeutic target but a transcript annotation overlapping the TAF15 locus. \n- TAF15 is a well-characterized protein with important biological roles, but the queried entity ("novel transcript, sense overlapping TAF15", ENSG00000270894) is not itself considered a standard drug target, and may be a non-functional RNA or a transcript with unclarified biological relevance[1]. \n- If you are seeking information on the TAF15 protein itself, refer to "TATA-binding protein-associated factor 15 (TAF15)" as the canonical entity. \n- No drugs are known to target ENSG00000270894 or TAF15 directly.\n\nSources: [1][3][4]

Other names

TAF15Npl3RBP56TAF2NTAFII68TATA-box binding protein associated factor 15