TATA-binding protein-associated factor 172 (BTAF1)

TATA-binding protein-associated factor 172 (BTAF1) is a protein that forms part of the B-TFIID complex by associating with TATA box-binding protein (TBP), which is essential for the initiation of transcription by RNA polymerase II[1][2][3][5][7]. BTAF1 possesses DNA-dependent ATPase and helicase activities, enabling it to dissociate TBP from DNA in an ATP-dependent manner, facilitating redistribution of TBP to other promoters, including those lacking a classical TATA box[1][2][3][7]. This regulatory function helps control access and specificity of the transcriptional machinery[6]. Diseases associated with BTAF1 include autism spectrum disorder, but there is little evidence for a direct role in common therapeutically-modulated diseases[1]. BTAF1 is not generally considered a therapeutic drug target and no drug interactions or mechanisms are listed in current biomedical databases[1][5][7].

Other names

B-TFIID TATA-box binding protein associated factor 1ATP-dependent helicase BTAF1TAF172TAFII170MOT1BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170 kDa (Mot1 homolog, S. cerevisiae)TBP-associated factor 172TAF-172TAF(II)170Mot1 homolog (S. cerevisiae)