TATA-box binding protein associated factor 11 like 3 (TAF11L3)

TAF11L3 encodes a protein structurally similar to TATA-box binding protein associated factor 11 (TAF11), both predicted to be components of the TFIID transcription factor complex that initiates RNA polymerase II-dependent transcription. TFIID is a large multiprotein complex, composed of TATA-box binding protein (TBP) and multiple TBP-associated factors (TAFs), that coordinates the assembly of the transcription preinitiation complex and mediates regulatory signals[2][3][5][1]. TAF11L3 is predicted, not confirmed, to contribute to general transcription initiation and to be expressed in the nucleus, with no direct evidence of clinical application or drug interactions. Its functional annotation is mainly based on paralogy and structural homology to TAF11, which directly interacts with TBP and other basal transcription factors in promoter recognition and stabilization of the preinitiation complex[3][1][5]. Overall, TAF11L3 remains a gene with limited empirical data regarding disease, drug interaction, or specific therapeutic roles.

Other names

TATA-box-binding protein-associated factor 11-like protein 3TAF11 RNA polymerase IITATA box binding protein (TBP)-associated factor, 28kDa pseudogeneTAF11L3