TATA-box binding protein associated factor 2 (TAF2)

TATA-box binding protein associated factor 2 (TAF2) is a protein encoded by the *TAF2* gene in humans and is a major subunit of the transcription factor IID (TFIID) complex. TFIID is essential for the initiation of transcription by RNA polymerase II, serving as a scaffold for the assembly of the pre-initiation complex and a conduit for regulatory signals during promoter activation. TAF2 is stably associated with TFIID and contributes to promoter DNA binding, interacting at and downstream of transcription start sites to facilitate transcription complex responsiveness to activators. Structurally, TAF2 contains a histone-like fold domain, contributing to protein-protein interactions within TFIID. Pathogenic variants in TAF2 can result in neurodevelopmental disorders, including leukodystrophy. TAF2 is not a direct therapeutic target and no drugs are known to modulate its activity.

Other names

TAFII150CIF150TAF2BTAFIIBMRT40150 kDa cofactor of initiator functionTranscription initiation factor TFIID 150 kDa subunitRNA polymerase II TBP-associated factor subunit BTATA box binding protein (TBP)-associated factor, 150 kDaTAF2 RNA polymerase II