TATA-box binding protein associated factor 6 like (TAF6L)

TAF6L is a transcription coactivator protein encoded by the *TAF6L* gene and is a component of the PCAF histone acetylase complex, which is involved in chromatin remodeling via histone acetylation and in regulating gene expression through interactions with RNA polymerase II machinery. TAF6L is structurally similar to TAF6 and shares the signature histone-like fold domain (HFD) found in TBP-associated factors. As part of the PCAF complex, TAF6L is implicated in myogenic transcription, differentiation, and orchestration of gene expression programs required for maintaining embryonic stem cell identity and somatic cell reprogramming. TAF6L interacts with other transcriptional regulators such as TAF9 and SPT3 homolog, and it is part of regulatory networks controlling RNA polymerase II pause release, especially in cooperation with MYC. While functionally essential for transcription and chromatin state, TAF6L has not been established as a direct therapeutic target or biomarker but may be indirectly involved in disease processes such as cancer through its transcriptional and epigenetic regulatory roles.

Other names

PAF65APAF65-alphaPCAF-associated factor 65-alphaTAF6LTAF6-like RNA polymerase II P300/CBP-associated factor-associated factor 65 kDa subunit 6LP300/CBP-associated factor (PCAF)-associated factor 65TAF6-like RNA polymerase II, PCAF-associated factor, 65kDa