TATA-box binding protein associated factor 9 (TAF9)

TATA-box binding protein associated factor 9 (TAF9) is a highly conserved subunit of the transcription factor IID (TFIID) complex, which is crucial for the initiation of transcription by RNA polymerase II. TFIID consists of the TATA-binding protein (TBP) and multiple TBP-associated factors (TAFs), including TAF9. TAF9 acts as a coactivator in transcriptional regulation, participating in both activation and repression of gene transcription, in part through direct interactions with transcriptional activators such as p53 and VP16, as well as several other TAFs and general transcription factors. TAF9 is essential for cell viability and gene expression, forming part of several chromatin-associated complexes involved in promoter recognition and pre-initiation complex assembly. Its ability to stabilize and regulate p53 links it to apoptosis and potential roles in cancer biology. No approved therapeutic drugs specifically target TAF9; direct targeting would likely pose significant safety concerns due to its central role in general transcription[1][2][3][4].

Other names

TAF9TAF2GTAFII31TAFII-31TAFII-32TAFII32TAFIID32MGC5067CGI-137MGC1603MGC3647AD-004RNA polymerase II TBP-associated factor subunit GSTAF31/32Transcription initiation factor TFIID 31 kDa subunitTranscription initiation factor TFIID 32 kDa subunit