TATA-box binding protein associated factor 9b pseudogene 2 (TAF9BP2)

TAF9BP2 (TATA-box binding protein associated factor 9b pseudogene 2) is officially described in human genomics databases as a pseudogene—a non-functional segment of DNA that resembles the functional gene for TAF9B, a protein associated with RNA polymerase II transcription initiation complexes such as TFIID[1][3][8]. As a pseudogene, TAF9BP2 is not transcribed into a functional protein, does not have recognized biological roles, is not considered a therapeutic or druggable target, and is not associated with human disease. The parent functional gene, TAF9B, encodes a bona fide factor involved in basal transcription and apoptosis[4][5], but TAF9BP2 itself does not encode a protein and is considered "dead" or non-functional in humans. Key Points: - TAF9BP2 is a pseudogene, not a functional protein-coding gene[1][3][8]. - It is incorrectly identified as a therapeutic target; it serves no role in molecular pharmacology or therapeutic intervention. - It should not be confused with TAF9B or TBP-associated factor 9b, which are related but functional genes/proteins involved in transcription initiation[1][4][5]. The presence of "pseudogene" in its canonical name and human gene annotations unequivocally indicate its non-functional status.

Other names

TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa pseudogene 2TAF9BP2[1][3]

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