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TATA-box binding protein-associated factor RNA polymerase I subunit A (TAF1A)
- Target
- TAF1A
- Molecular classification
- Transcription factor (component of SL1), RNA polymerase I-associated factor, Protein coding
01
Overview
TATA-box binding protein-associated factor RNA polymerase I subunit A (TAF1A) is a protein component of the SL1 transcription factor complex, which is essential for RNA polymerase I-mediated transcription initiation of ribosomal RNA (rRNA) genes. TAF1A helps assemble the pre-initiation complex at rDNA promoters, stabilizes UBTF binding, and channels regulatory signals for rRNA synthesis, a central process for ribosome assembly and cellular protein synthesis. SL1, containing TBP and several TAFs including TAF1A, specifically positions RNA polymerase I at rDNA promoters for accurate initiation of transcription. Defective TAF1A function can impair ribosome production and has been associated with cardiac diseases.
- Other names
- TAFI48SL1TATA box-binding protein-associated factor RNA polymerase I subunit ARNA polymerase I-specific TBP-associated factor 48 kDaTBP-associated factor 1ATATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDaTranscription factor SL1Transcription initiation factor SL1/TIF-IB subunit ARAFI48MGC:17061
02
Biological functions
Transcription initiation (by RNA polymerase I)Assembly of pre-initiation complex for rRNA gene transcriptionStabilization of nucleolar transcription factor 1/UBTF on rDNA
03
Disease associations
Familial isolated dilated cardiomyopathyAtrial standstill 1Other ribosomopathies (possible but not definitively cited)
04
Safety considerations
Mutations may be linked to cardiomyopathy or arrhythmiaDisruption could affect ribosomal RNA synthesis, impacting cell growth/proliferation
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