TatD DNase domain containing 1 (TATDN1)

TatD DNase domain containing 1 (TATDN1) is a conserved cytoplasmic enzyme containing a DNase domain, widely expressed in vertebrates and implicated in several critical cellular processes. While initially identified for its potential DNA degradation function in prokaryotes, mammalian TATDN1 no longer participates in DNA degradation but rather is upregulated in response to proteostasis stress, playing a role in protein homeostasis and structural integrity of cardiac and neurological tissues. In zebrafish and other model organisms, TATDN1 displays DNase and DNA decatenation activity, affecting chromosome segregation and cell cycle progression during development, especially in the eye. Knockdown or deficiency of TATDN1 leads to dilated cardiomyopathy, impaired motor coordination, and abnormal eye formation, demonstrating its physiological significance. TATDN1 is associated with several diseases, including cancer and cardiovascular disorders, and has been proposed as a putative biomarker for certain cancer types, though no drugs currently target this enzyme directly in clinical practice.

Other names

TATDN1Deoxyribonuclease TATDN1CDA11Hepatocarcinoma high expression proteinPutative deoxyribonuclease TATDN1

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