Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Tau phosphorylated at Serine 422 (Tau pS422)
- Target
- Tau pS422
- Molecular classification
- Microtubule-associated protein, Phosphoprotein
01
Overview
Tau phosphorylated at Serine 422 (Tau pS422) is a post-translational modification of the tau protein, specifically the phosphorylation of serine residue 422. This modification is a key pathological marker in Alzheimer's disease and other tauopathies. Phosphorylation at S422 disrupts tau's normal function of stabilizing microtubules, leading to cytoskeletal destabilization and neurofibrillary tangle formation. It serves as a diagnostic biomarker and a potential therapeutic target for immunotherapy.
- Other names
- Phospho-Tau Ser422p-Tau Ser422Tau phosphorylated at S422
02
Mechanism of action
Inhibition of tau phosphorylation
03
Biological functions
Microtubule stabilizationAxonal transport regulationNeuronal structure maintenance
04
Disease associations
Alzheimer's diseaseTauopathiesNeurodegenerative disease
05
Safety considerations
Targeting tau phosphorylation may have unintended effects on normal tau function
06
Interacting drugs
Acetylsalicylic acid
07
Biomarkers
Alzheimer's diseaseTauopathiesNeurodegeneration
Beyond the preview
Go deeper on Tau phosphorylated at Serine 422 (Tau pS422).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Tau phosphorylated at Serine 422 (Tau pS422).