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Tau Phosphorylation (TauP)

Target: TauP
Molecular classification: Other - Post-translational modification

Overview

Tau phosphorylation is a critical post-translational modification of tau protein, which plays a key role in stabilizing microtubules in neurons. Abnormal hyperphosphorylation of tau leads to neurodegenerative diseases like Alzheimer's by disrupting microtubule stability and promoting tau aggregation. Drugs targeting tau phosphorylation aim to modulate this process to prevent or treat neurodegeneration.

Other names: Tau HyperphosphorylationAbnormal Tau Phosphorylation

Mechanism of action

Inhibiting tau kinases, enhancing tau phosphatase activity, or modulating other signaling pathways to reduce pathological tau phosphorylation.

Biological functions

Microtubule stabilizationSignal transductionAxonal transport

Disease associations

Neurodegenerative disease (e.g., Alzheimer's disease)Tauopathies

Safety considerations

The challenge lies in selectively targeting pathological tau phosphorylation without affecting normal tau function.

Interacting drugs

Drugs targeting tau phosphorylation often include those inhibiting tau kinases like GSK-3β or promoting tau phosphatases like PP2A. Examples of drugs in research include lithium, which inhibits GSK-3β.

Biomarkers

Phosphorylated tau proteins, especially at specific sites like Ser396/Ser404, are used as biomarkers for tauopathies.

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