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Target intelligence / Profile preview
Microtubule-associated protein (MAP)
- Target
- MAP
- Molecular classification
- Protein, Microtubule-binding protein
01
Overview
Microtubule-associated proteins (MAPs) are a diverse group of proteins that interact with microtubules, regulating their stability, organization, and function. They play essential roles in cell shape, transport processes, division, migration, and neuronal development and function. MAPs bind to tubulin subunits, promoting polymerization or depolymerization, and guiding microtubules to specific cellular locations. Their binding affinity is regulated by phosphorylation. Notable members include Tau protein, APC, MAP1, MAP2 and MAP4 families.
- Other names
- MAPsTau proteinAPC (+TIP regulator)MAP1 familyMAP2MAP4
02
Mechanism of action
Phosphorylation-dependent attachment/detachment via kinases such as MARK
03
Biological functions
Stabilize microtubulesDestabilize microtubulesGuide microtubule localizationMediate microtubule-protein interactionsOrganize internal structure of cellsSupport intracellular transportCell divisionCell migrationAxonal growthAxonal maintenancemRNA translation (Tau protein)
04
Disease associations
Neurodegenerative diseasesCancer
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