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Target intelligence / Profile preview
Tau Protein Aggregation (N/A)
- Target
- N/A
- Molecular classification
- Protein aggregate, Pathological protein conformer
01
Overview
Tau protein aggregation refers to the abnormal self-association of tau proteins into larger, insoluble clusters within neurons. This process is a pathological hallmark of Alzheimer's disease and over twenty other neurodegenerative disorders collectively known as tauopathies. Normally, tau stabilizes microtubules in neuronal axons, but when it aggregates, it disrupts microtubule function and leads to neuronal degeneration and loss. Inhibiting or reversing tau aggregation is a major therapeutic strategy for treating Alzheimer's disease and other tauopathies.
- Other names
- Tau aggregatesPaired helical filaments (PHFs)Straight filaments (SFs)
02
Mechanism of action
Inhibition or reversal of tau aggregation; modulation of tau phosphorylation
03
Biological functions
Microtubule disruptionImpaired axonal transportNeuronal degeneration
04
Disease associations
Alzheimer's diseaseTauopathiesNeurodegenerative disease
05
Safety considerations
Off-target effects of aggregation inhibitorsBlood-brain barrier penetration for drugs targeting tauComplexity of the aggregation pathway and potential for unintended consequencesTargeting of normal tau protein function
06
Biomarkers
Levels of tau aggregates in cerebrospinal fluid (CSF)Levels of phosphorylated tau (p-tau) in CSFPET imaging of tau aggregates in the brain
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