Taura syndrome virus polyprotein (TSV polyprotein)

Taura syndrome virus (TSV) is a major pathogen belonging to the family Dicistroviridae, primarily impacting the Pacific white shrimp (Penaeus vannamei) (Source: OIE, 2019). The TSV genome consists of a single-stranded, positive-sense RNA that encodes two large polyproteins: ORF1, which produces non-structural proteins like RNA-dependent RNA polymerase (RdRp), helicase, and protease, and ORF2, which produces structural capsid proteins VP1, VP2, and VP3 (Source: UniProt, P89873). These proteins are essential for the viral life cycle, including genome replication and the assembly of icosahedral virions that infect the cuticular epithelium of the host (Source: ICTV). In aquaculture, these proteins are targeted by experimental RNA interference (RNAi) therapies and DNA vaccines to induce protective immunity or silence viral gene expression (Source: PubMed, PMID: 15652311). Understanding the structure and function of these proteins is critical for developing diagnostic tools and biosecurity measures to control the spread of Taura syndrome, which can cause up to 95% mortality in affected shrimp populations.

Other names

TSV capsid proteinTSV VP1TSV VP2TSV VP3Taura syndrome virus non-structural proteinTSV ORF1 polyproteinTSV ORF2 polyprotein

RNA interference (RNAi) mediated gene silencing of viral mRNA to inhibit translation and replication, and antibody-mediated neutralization of structural capsid proteins to prevent viral entry into host cells (Source: PubMed, PMID: 15652311).