Solute carrier family 6 member 6 (SLC6A6)

Solute carrier family 6 member 6 (SLC6A6), also known as the taurine transporter (TauT), is a sodium- and chloride-dependent membrane transporter highly expressed in many tissues, including the heart, brain, kidney, and retina. This transporter is critical in regulating cellular taurine levels, impacting osmoregulation, antioxidative defense, and membrane stabilization, and is involved in protecting tissues against ischemic and neurotoxic damage. Dysregulation of the taurine transporter and taurine uptake has been implicated in cardiac dysfunction, neurodegenerative disorders, retinal degeneration, and diabetes. SLC6A6 is considered a valid drug target due to its central role in taurine balance and associated pathologies[3]. *Note*: Your request is for "Solute carrier family 6 member 6" (SLC6A6, taurine transporter), distinct from "solute carrier family 16 member 6" (SLC16A6, monocarboxylate transporter) and others in the SLC family. If you intended a different member, please specify.

Other names

Taurine transporterTauTSLC6A6Sodium- and chloride-dependent taurine transporter

Competitive inhibition (blockers of taurine binding to the transporter) Substrate competition (other similar molecules or analogues compete with taurine)