Tax1-binding protein 1 (TAX1BP1)

Tax1-binding protein 1 (TAX1BP1) is a ubiquitin-binding adaptor and autophagy receptor protein central to regulating the immune response and selective autophagy. By interacting with ubiquitinated signaling proteins such as TRAF6 and RIPK1, TAX1BP1 recruits the deubiquitinating enzyme A20 (TNFAIP3) to disrupt key pro-inflammatory signaling pathways, including the NF-kappaB and IRF3 pathways, thereby negatively regulating inflammation and antiviral responses[1][4][5][7]. TAX1BP1 is also essential for xenophagic clearance of pathogenic bacteria—targeting bacteria like Salmonella and Mycobacterium for autophagy-mediated degradation via its zinc finger ubiquitin-binding domains and selective interaction with autophagy machinery[2][4]. Mutations or disruption in TAX1BP1 function can impair immune regulation, autophagy, and cellular homeostasis, with potential implications in inflammatory disease, cancer, infection, and neurological disorders such as Parkinson disease[5]. No clinically approved drugs directly target TAX1BP1, but the protein is of significant research interest for its multifaceted role at the intersection of autophagy and immune signaling.

Other names

TAX1BP1T6BPPRO0105TXBP151CALCOCO3TRAF6-binding proteintax1-binding protein 1Tax1 (human T-cell leukemia virus type I) binding protein 1

No approved drugs directly targeting TAX1BP1, hence no direct mechanisms of action defined; TAX1BP1 modulation occurs via its role in key signaling pathways.