TBC1 domain family member 10B (TBC1D10B)

TBC1 domain family member 10B (TBC1D10B) is a protein-coding gene that encodes a GTPase-activating protein (GAP) for several Rab family small GTPases, including RAB3A, RAB22A, RAB27A, and RAB35, but not RAB2A or RAB6A[1][8]. Through its GAP activity, TBC1D10B inactivates these Rab proteins to regulate intracellular vesicle trafficking, including exocytic and endocytic processes[1][2][8]. TBC1D10B expression is upregulated in several cancers, most notably hepatocellular carcinoma and gastric adenocarcinoma, where its high expression correlates with worse clinical outcomes[2]. It modulates biological pathways involved in cell cycle regulation, extracellular matrix organization, and tumor immune microenvironment[2]. TBC1D10B is also associated with genetic disorders such as Griscelli syndrome type 3[1]. It is considered a potential prognostic biomarker and may represent a novel immune therapeutic target, though no approved drugs currently target TBC1D10B directly[2][1].

Other names

TBC1D10BEPI64BRab27A-GAP-betaRab27A-GAPbetaFP2461DKFZP434P1750FLJ13130

Not applicable for specific drugs (primarily functions as a GTPase-activating protein for Rab family members); alteration of TBC1D10B activity may affect vesicle trafficking pathways, cell proliferation, and cell cycle regulation[1][2][8].