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Target intelligence / Profile preview
TBC1 domain family member 12 (TBC1D12)
- Target
- TBC1D12
- Molecular classification
- Other (contains TBC/Rab-GAP domain; not classified as receptor, transporter, ion channel, GPCR, enzyme in conventional sense)
01
Overview
TBC1 domain family member 12 (TBC1D12) is a human protein encoded by the TBC1D12 gene, containing a conserved TBC (Tre-2/Bub2/Cdc16) domain, generally associated with GTPase-activating proteins for Rab family small GTPases. TBC1D12 is predicted to enable GTPase activator activity, playing roles in regulation of autophagosome assembly and intracellular vesicular transport, particularly in endosomal compartments. It is also implicated as a RAB11A-binding protein with a function in neurite outgrowth. Currently, TBC1D12 is not a therapeutic target, and no drugs are known to interact with it.
- Other names
- TBC1D12KIAA0608TBC1 domain family, member 12
02
Biological functions
GTPase activator activityRegulation of autophagosome assemblyIntracellular protein transportRegulation of vesicle fusionNeurite outgrowth
03
Disease associations
Brachydactyly, type D (no strong evidence for other disease links based on current sources)
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