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Target intelligence / Profile preview
TBC1 domain family member 26 (TBC1D26)
- Target
- TBC1D26
- Molecular classification
- Other (TBC domain–containing protein, putative GTPase-activating protein)
01
Overview
TBC1 domain family member 26 (TBC1D26) is a human protein encoded by the TBC1D26 gene, which may act as a GTPase-activating protein for Rab family proteins, according to sequence homology and domain analysis[1][9]. The gene is predicted to enable GTPase activator activity and may be involved in the activation of GTPase activity and intracellular protein transport, but there is no confirmed evidence for a functional or disease-related role in humans[6]. The symbol "ENSG00000277252" corresponds to a pseudogene—a segment of DNA that resembles a gene but is non-functional, i.e., not known to encode a protein or participate in cellular signaling for therapeutic targeting. There are no known drug interactions, disease roles, or safety considerations. Accordingly, TBC1 domain family member 26 pseudogene (ENSG00000277252) is not a validated therapeutic target, and there is a critical issue with the query: the entry is a pseudogene rather than an established target[1][6].
- Other names
- TBC1D26MGC51025TBC1 domain family member 26
02
Biological functions
GTPase activator activity (predicted)possible involvement in intracellular protein transportNo well-defined biological function in human physiology or disease
03
Disease associations
None known; no validated association with disease
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