TBC1 domain family member 30 (TBC1D30)

**TBC1 domain family member 30 (TBC1D30)** is a protein encoded by the TBC1D30 gene on human chromosome 12 (12q14.3)[1]. The protein contains a RabGAP-TBC domain and a DUF4682 domain, suggesting a putative function as a GTPase-activating protein for Rab family proteins, which are involved in vesicular trafficking[2][5]. TBC1D30 is predominantly expressed in the brain and adrenal cortex[1][3]. Experimental studies indicate roles in the regulation of cilium assembly/disassembly and possible involvement in insulin processing[1][4]. There are no approved drugs or direct therapeutics targeting this molecule, and its clinical significance remains largely uncharacterized. Possible protein-protein interactions include STX3, ZRANB1, and ESR1[1]. A single nucleotide polymorphism (rs11615287) in the RabGAP domain may be damaging, but current evidence does not specifically link TBC1D30 to major human diseases or therapeutic interventions[1][4][5].

Other names

TBC1D30KIAA0984

Not applicable (no drugs known to interact)