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Target intelligence / Profile preview
TBC1 domain family member 31 (TBC1D31)
- Target
- TBC1D31
- Molecular classification
- Other (multi-domain adapter protein involved in cellular signaling/structure), TBC domain family protein
01
Overview
TBC1 domain family member 31 is a structural and molecular adapter protein encoded by the TBC1D31 gene and identified also as WDR67[3][6][7]. It is involved in the assembly of cilia, located at cellular structures such as the Golgi apparatus, centriolar satellite, and ciliary basal body[3][7]. TBC1D31 forms functional complexes with proteins like OFD1, potentially regulating their post-translational modifications including cAMP-dependent phosphorylation and ubiquitination[3]. In cancer biology, elevated TBC1D31 expression correlates with metabolic reprogramming (glycolytic phenotype) and is a prognostic biomarker in triple-negative breast cancer, suggesting a mechanistic link to aggressive cancer behavior[4]. There are currently no approved drugs directly targeting this protein in clinical settings.
- Other names
- WD repeat domain 67WD repeat-containing protein 67WDR67
02
Mechanism of action
no approved drugs, mechanisms in experimental models involve metabolic pathway modulation
03
Biological functions
Cilium assembly and biogenesisMolecular adaptor activityRegulation of cell signaling (possible cAMP-dependent phosphorylation)Possible involvement in membrane trafficking and metabolism regulation
04
Disease associations
Cancer (prognostic biomarker and possible driver in triple-negative breast cancer, TNBC)Genitourinary tract anomalies
05
Biomarkers
Prognostic in triple-negative breast cancer (elevated expression predicts worse outcome)
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