TBC1 domain family member 3B (TBC1D3B)

TBC1 domain family member 3B (TBC1D3B) is a human protein belonging to the TBC1 domain family, which are known as GTPase-activating proteins (GAPs) for Rab small G proteins. TBC1D3B specifically acts as a GAP for Rab5, a protein central to vesicle trafficking and endocytosis, but does not act on Rab4 or Rab11[1][2][4]. It contains a TBC (Tre-2, Bub2, and Cdc16) domain, which is characteristic of proteins involved in the regulation of RAB GTPase signaling, impacting vesicle trafficking steps such as receptor internalization, recycling, and degradation[1][2][3][4]. This gene is located within a cluster on chromosome 17q and includes several similar copies or paralogs[2][6]. TBC1D3B may play roles in cellular processes that depend on the control of vesicular transport, indirectly influencing pathways of cell signaling, proliferation, and possibly cancer progression, though it is not established as a direct therapeutic target. Diseases associated with TBC1D3B include prostate cancer and ceroid lipofuscinosis, neuronal, 7, with suggested but poorly defined roles in cancer[2]. However, no approved drugs are currently known to target it, and it is not described as a biomarker or with specific safety concerns in available datasets[2][3][4].

Other names

PRC17TBC1D3ITBC1D3LTBC1 domain family member 3ITBC1 domain family, member 3-likeRab GTPase-activating protein PRC17 duplicateprostate cancer gene 17 duplicate