TBC1 domain family member 3D (TBC1D3D)

TBC1 domain family member 3D (TBC1D3D) is a primate-specific protein belonging to the TBC domain family, originally identified as an oncogene in prostate and breast cancer. TBC1D3D has a TBC (Tre-2, Bub2, Cdc16) domain, which typically confers GTPase-activating activity for Rab GTPases, though TBC1D3D is a Rab5 effector rather than an active GAP. It enhances cell proliferation by augmenting EGFR and Ras signaling, primarily by delaying EGFR degradation and suppressing its ubiquitination. TBC1D3D also reprograms the protein and transcription factor payloads of extracellular vesicles released by immune cells, influencing wound healing, tissue repair, and inflammation. It is linked to cancer development, chromosome 17q12 deletion syndrome, and other human-specific processes. TBC1D3D has several close paralogs and aliases due to gene duplication events in primates, and its role in disease and physiology is still being elucidated, especially in regards to its regulatory functions in cell growth, signaling, and vesicle trafficking[1][2][3][4].

Other names

TBC1D3DPRC17TBC1D3TBC1D3ATBC1D3HProstate cancer gene 17 proteinRab GTPase-activating protein PRC17TBC1 domain family member 3TBC1 domain family, member 3HTRE17 alpha protein

Modulates growth factor receptor (EGFR) signaling by impairing receptor ubiquitination and degradation; Acts as a Rab5 effector, impacting GTP loading and trafficking; Alters payload and activity of extracellular vesicles released by myeloid cells, affecting cell signaling and tissue repair; Enhances Ras activation and downstream signaling pathways (Erk, Akt)