TBC1 domain family member 8 antisense RNA 1 (TBC1D8-AS1)

TBC1 domain family member 8 antisense RNA 1 (TBC1D8-AS1) is a **long non-coding RNA (lncRNA)** transcribed antisense to the TBC1D8 gene and located on chromosome 2[1][5]. As a non-coding RNA, it does not encode a protein but is believed to regulate the expression of its sense partner gene, TBC1D8, possibly through antisense transcript-mediated effects[1][5]. Evidence suggests it may participate in the regulation of **Wnt signaling** by inducing secreted Wnt antagonists, thereby modulating canonical Wnt pathway activity[7]. TBC1D8-AS1 has been implicated in the pathophysiology of cancers and possibly other disease contexts, but it is not a classical drug target such as an enzyme, receptor, or transporter[5][7]. There are no known drugs that directly target TBC1D8-AS1, and it does not serve as a common predictive biomarker in current clinical practice.

Other names

TBC1D8-AS1TBC1D8 antisense RNA 1