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TBC1 domain family member 9 (TBC1D9)
- Target
- TBC1D9
- Molecular classification
- Other, Rab GTPase-activating protein (GAP) family, EF-hand-containing protein
01
Overview
TBC1 domain family member 9 (TBC1D9) is a protein encoded by the TBC1D9 gene in humans and belongs to the TBC (Tre-2/Bub2/Cdc16) domain family, known for functioning as GTPase-activating proteins (GAPs) for Rab family small GTPases involved in membrane trafficking[5][7]. TBC1D9 contains two GRAM domains, a TBC domain, and an EF-hand motif, supporting roles in calcium binding, protein trafficking, and vesicle transport, particularly in endosomes and the Golgi[1][3]. It is implicated in the regulation of TBK1 activation during autophagy-related processes such as xenophagy and mitophagy in a calcium-dependent manner[1]. High TBC1D9 expression has been found in testicular germ cells and is involved in vesicular trafficking pathways related to Rab7 and Rab9[3]. In cancer biology, related TBC1 domain proteins are associated with metabolic phenotype regulation, but specific biomarker or drug targeting evidence for TBC1D9 is lacking[2][7].
- Other names
- TBC1D9KIAA0882GRAMD9MDR1TBC1 domain family member 9ATBC1D9ATBC1 domain family, member 9 (with GRAM domain)
02
Biological functions
Intracellular protein transportRegulation of membrane traffickingGTPase activator activity for Rab proteinsCalcium ion bindingModulation of TBK1 activation (implicated in xenophagy and mitophagy)
03
Disease associations
Cancer (specifically implicated in breast cancer metabolism modulation)Non-proliferative fibrocystic change of the breast
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