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Target intelligence / Profile preview
TBC1 domain family member 9 antisense RNA 1 (TBC1D9-AS1)
- Target
- TBC1D9-AS1
- Molecular classification
- Long non-coding RNA (lncRNA), Antisense RNA, Non-coding RNA, Other
01
Overview
TBC1 domain family member 9 antisense RNA 1 (TBC1D9-AS1) is a long non-coding RNA (lncRNA) transcribed antisense to the TBC1D9 gene. Like other antisense RNAs, TBC1D9-AS1 is thought to regulate expression of its sense counterpart (TBC1D9) or other genes through mechanisms such as transcriptional interference, chromatin modification, or mRNA stability. Antisense RNAs such as TBC1D9-AS1 are generally important for fine-tuning gene expression and have been shown to play roles in both normal physiology and disease by affecting gene regulation at multiple stages, but no literature directly implicates TBC1D9-AS1 in human disease or establishes it as a direct therapeutic target at this time.
- Other names
- TBC1D9 antisense RNA 1TBC1D9-AS1
02
Biological functions
Regulation of gene expression at transcriptional and post-transcriptional levelsModulation of neighboring gene (sense) TBC1D9 expressionPotential cis- and/or trans-regulation of chromatin structure or mRNA stabilityOther
03
Disease associations
At present, there are no direct references linking TBC1D9-AS1 specifically to disease in the indexed literature; however, dysregulation of antisense lncRNAs can be implicated in cancer and other disease contexts in general.
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