Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
TBCC domain-containing protein 1 (TBCCD1)
- Target
- TBCCD1
- Molecular classification
- Other (centrosomal protein), TBCC domain-containing protein family, Cytoskeleton-associated protein
01
Overview
TBCC domain-containing protein 1 (TBCCD1) is a centrosomal protein related to tubulin cofactor C. It localizes primarily at the centrosome, spindle midzone, and basal bodies of primary and motile cilia. TBCCD1 depletion causes centrosome and Golgi disorganization, slows cell migration, and impairs primary cilia assembly, indicating its central role in internal cell organization and the dynamics of the cytoskeleton. TBCCD1 has homologs conserved across eukaryotes and contains both a TBCC domain, important for microtubule function, and a CARP domain, suggesting possible links between microtubule and actin cytoskeletons. Unlike TBCC or RP2, TBCCD1 does not share GTPase-activating protein (GAP) activity towards tubulin, but its full molecular functions are not yet entirely defined[1].
- Other names
- TBCC domain-containing protein 1TBCCD1FLJ10560
02
Mechanism of action
None known. There are no described pharmacological mechanisms of action for drugs targeting TBCCD1[1].
03
Biological functions
Centrosome positioningGolgi apparatus organizationCell migrationAssembly of primary ciliaCytoskeletal organization (potential crosstalk between microtubule and actin networks)
04
Disease associations
Other. TBCCD1’s dysfunction affects cell migration, centrosome–nucleus association, and cilia formation, which could contribute to developmental or ciliopathy disorders. However, no direct link to a specific named human disease (e.g., cancer, neurodegenerative disease) is currently established.
Beyond the preview
Go deeper on TBCC domain-containing protein 1 (TBCCD1).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on TBCC domain-containing protein 1 (TBCCD1).