TCDD-inducible poly(ADP-ribose) polymerase (TIPARP)

TCDD-inducible poly(ADP-ribose) polymerase (TIPARP, also known as Poly(ADPr)-polymerase 7 or PARP7), is a member of the poly(ADPr)-polymerases (PARPs), a protein family involved in post-translational modification through ADPr transfer from NAD+ onto substrate proteins. Unlike canonical members such as PARP1 that catalyze formation of long branched polymers ("poly"-ribosylation), TIPARP primarily mediates mono ADPr transfer ("mono"-ribosylation). The biological functions attributed to this enzyme include regulation of gene expression via chromatin remodeling and modulation of cellular responses following exposure to environmental toxins such as dioxins. While much research has focused on other family members like PARP1/2 due to their central role in DNA repair pathways—and thus their value as cancer drug targets—emerging evidence suggests that selective inhibition or modulation of enzymes like TIPARP could have therapeutic potential but requires further study regarding specificity, efficacy, and safety profiles. Note: The submitted name "Poly polymerase 7" does not conform with accepted nomenclature; the correct designation should be TCDD-inducible poly(ADPr)-polymerase (TIPARP/PARP7).

Other names

PARP7TIPARPPoly(ADP-ribose) polymerase 7

For general PARPs: Inhibition leads to impaired DNA repair and synthetic lethality in cells with defective homologous recombination. For TIPARP: Likely involves inhibition of mono ADP-ribosylation activity on specific substrates.