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Target intelligence / Profile preview
TCF21 antisense RNA inducing promoter demethylation (TARID)
- Target
- TARID
- Molecular classification
- Long noncoding RNA (lncRNA), Antisense RNA
01
Overview
TARID is a long noncoding RNA that functions as an epigenetic regulator by inducing demethylation of the TCF21 promoter. This process involves interaction with GADD45A and results in increased expression of TCF21, which is a tumor suppressor gene frequently silenced by hypermethylation in cancer. TARID plays a role in regulating gene expression and is implicated in diseases where TCF21 expression is crucial.
- Other names
- EYA4-AS1EYA4 antisense RNA 1
02
Mechanism of action
Induces promoter demethylation through interaction with GADD45A and recruitment of DNA demethylating enzymes
03
Biological functions
Epigenetic regulationPromoter demethylationGene expression regulation
04
Disease associations
Cancer (specifically related to TCF21 expression and methylation)CardiomyopathyDeafness
05
Safety considerations
None specifically mentioned; however, manipulation of epigenetic markers like TARID could have unforeseen effects on gene expression and cellular behavior
06
Biomarkers
TCF21 methylation status could be a biomarker related to cancer and potentially other diseases influenced by TARID
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