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Target intelligence / Profile preview
TEA Domain Family Member (TEAD) Transcription Factors (TEAD)
- Target
- TEAD
- Molecular classification
- Transcription factor
01
Overview
The TEA domain family member (TEAD) transcription factors are a group of highly conserved proteins that play crucial roles in gene regulation, development, and disease. In humans, there are four main TEAD genes: TEAD1, TEAD2, TEAD3, and TEAD4. These proteins are characterized by the presence of a conserved DNA-binding region known as the "TEA domain". TEADs regulate genes controlling growth/development/apoptosis and are associated with cancer progression/proliferation/metastasis/stemness.
- Other names
- Transcriptional enhancer factor (TEF)TCF-13 (for TEAD1)
02
Mechanism of action
Small-molecule inhibitors targeting the palmitate-binding pocket within the C-terminal cofactor-interaction domain of mammalian TEADs disrupt auto-palmitoylation and block interaction with cofactors like YAP/TAZ.
03
Biological functions
Transcription regulationCell proliferationCell survivalCell differentiationOrgan developmentApoptosis regulationStemness maintenance
04
Disease associations
CancerChemoresistance
05
Safety considerations
Context-dependent oncogenic or tumor-suppressor activityAberrant Hippo pathway activity
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