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Target intelligence / Profile preview
TEA Domain Transcription Factor 1 (TEAD1)
- Target
- TEAD1
- Molecular classification
- Transcription factor, TEA/ATTS domain family
01
Overview
TEAD1 is a transcription factor that regulates gene expression involved in embryonic development, organ formation, cell proliferation, differentiation, and apoptosis. It binds to DNA via the TEA domain and requires coactivators like YAP/TAZ for transcriptional activity. TEAD1 plays a role in the Hippo signaling pathway, controlling organ size and acting as a tumor suppressor. Dysregulation of TEAD1 has been linked to Sveinsson's chorioretinal atrophy and various cancers.
- Other names
- Transcriptional enhancer factor TEF-1TEA domain family member 1Transcription factor 13 (TCF-13)
02
Mechanism of action
Disruption of TEAD1-YAP/TAZ interaction (potential anti-cancer therapies)
03
Biological functions
Gene expression regulationEmbryonic developmentOrgan formationCell proliferationCell differentiationApoptosisHippo signaling
04
Disease associations
Sveinsson’s chorioretinal atrophyCancer
05
Safety considerations
Context-dependent tumor suppressor or promoter role in cancerPotential for off-target effects due to widespread expression
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