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TEA domain transcription factor 3 (TEAD3)
- Target
- TEAD3
- Molecular classification
- Transcription factor
01
Overview
TEAD3 is a member of the transcriptional enhancer factor (TEF) family of transcription factors. It contains a conserved DNA-binding domain known as the TEA/ATTS domain and plays a key role in the Hippo signaling pathway. It regulates gene expression by binding to specific DNA sequences and interacts with coactivators such as YAP1 and WWTR1/TAZ, influencing cell proliferation, migration, and epithelial-mesenchymal transition (EMT). TEAD3 is predominantly expressed in the placenta and also found in nervous system and muscle tissues. Its altered activity is implicated in various cancers, making it a potential target for pharmacological intervention.
- Other names
- DTEF-1ETFR-1TEAD-3TEAD5TEF-5TEF5Transcriptional enhancer factor 5[3]
02
Mechanism of action
Modulation of palmitoylation status or protein-protein interactions with YAP/TAZ coactivators
03
Biological functions
Transcription regulationOrgan size controlTumor suppressionCell proliferationCell differentiationCell growthApoptosis
04
Disease associations
Cancer
05
Safety considerations
Dysregulation or altered activity implicated in various cancers
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