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TEA domain transcription factor 4 (TEAD4)
- Target
- TEAD4
- Molecular classification
- Transcription factor
01
Overview
TEAD4 is a transcription factor belonging to the TEF family. It plays a crucial role in regulating gene expression by binding to DNA motifs and interacting with cofactors like YAP and TAZ. TEAD4 is involved in various biological processes, including organ size control, tumor suppression, and mitochondrial homeostasis. Its unique ability to modulate both nuclear and mitochondrial OXPHOS genes makes it a key regulator of cell proliferation, survival, and metabolism, especially in the context of cancer development and progression.
- Other names
- EFTR-2RTEF1TCF13L1TEF-3TEF3TEFR-1hRTEF-1B
02
Mechanism of action
Inhibition of TEAD4-cofactor interactions
03
Biological functions
Regulation of transcription by RNA polymerase IISkeletal system developmentMuscle organ developmentCell proliferationCell survivalTissue regenerationStem cell maintenanceEMT inductionMitochondrial homeostasis
04
Disease associations
Cancer
05
Safety considerations
Potential for off-target effects due to broad developmental rolesDisruption of mitochondrial function
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