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Target intelligence / Profile preview
TEAD Family of Transcription Factors (TEAD)
- Target
- TEAD
- Molecular classification
- Transcription factor, DNA-binding protein
01
Overview
The TEAD (TEA domain) family of transcription factors, including TEAD1, TEAD2, TEAD3, and TEAD4, are key regulators of gene expression involved in development, cell proliferation, and organ size regulation. They bind to specific DNA motifs and interact with co-activators like YAP/TAZ to influence the expression of genes involved in these processes. Dysregulation of TEADs has been implicated in various cancers.
- Other names
- Transcriptional enhancer associate domainTEA domain familyTEAD1TEAD2TEAD3TEAD4
02
Mechanism of action
TEAD proteins bind to DNA and interact with co-factors like YAP/TAZ to regulate the expression of target genes involved in cell proliferation, survival, and development.
03
Biological functions
Transcription regulationDevelopmentOrgan size controlCell proliferationCell survivalHippo signaling pathway
04
Disease associations
CancerDevelopmental disorders
05
Safety considerations
Aberrant activation in cancer leading to uncontrolled cellular proliferationPotential for off-target effects due to the widespread role of TEADs in various tissues
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