Tear film mucin of the ocular surface

The **tear film and mucus layer of the ocular surface** are a multi-layered structure essential for eye health and vision. The tear film comprises aqueous, mucous, and lipid layers; the **mucus layer**, rich in mucins (high-molecular weight glycoproteins), stabilizes the tear film, keeps the surface hydrated, provides lubrication, and protects against pathogens and mechanical insults[1][2][3][4]. Goblet cells in the conjunctiva secrete the principal gel-forming mucin, *MUC5AC*, which is vital for maintaining ocular surface moisture and immune homeostasis[3][1]. Dysfunction or deficiency of the mucins is linked with dry eye and other ocular surface disorders[1][2][3]. The term "Ocular surface tear film and mucus layer" should be refined to a more molecularly specific entity (such as "Mucins of the ocular surface" or "MUC5AC") for accurate bioinformatics or therapeutic targeting purposes.

Other names

Tear film mucinsOcular surface mucus layerOcular surface mucinsConjunctival mucins

Enhancement of mucin secretion or protection Immunomodulation (by increasing goblet cell and mucin function)